Royal Air Force Typhoon jets have operated alongside French warplanes in a coordinated attack against an underground arms cache in Syrian territory operated by the IS group, according to the British defence ministry.
The facility, pinpointed through surveillance, was believed to be containing munitions and bombs, the statement said, and was positioned in mountains just above the ancient city of Palmyra in the heart of Syria.
"Our fighter planes utilized precision-guided Paveway IV munitions to hit a number of access tunnels leading to the facility... early reports indicate the objective was successfully hit," officials stated.
There was no indication of any civilian casualties in the strike conducted Saturday night and each participating jet returned to base without incident, the ministry further stated.
The Typhoon FGR4s were supported by a Voyager aerial refuelling aircraft.
The Islamic State group - referred to as ISIS - enforced jihadist rule over significant areas in both Syria and Iraq prior to its 2019 collapse.
"This strike shows the UK's leading role, and resolve to stand shoulder to shoulder with allied nations, to eradicate any resurgence of Daesh and their harmful and extremist ideologies in the region," Britain's Defence Chief John Healey said.
RAF aircraft have performed overwatch operations over Syria to "deter any attempted comeback" of IS following its routing at the Baghuz confrontation in 2019, the MoD reported.
"I extend gratitude to the personnel of our armed forces involved in this operation for their professionalism and their valour," he said. "They were part of numerous British troops stationed over the holidays. This mission, to take out terrorist threats who pose a risk to our security, highlights how our armed forces are ready to step up, throughout the year, protecting the UK within its borders and strong abroad."
Last December, the United States armed forces executed what it termed a "major assault" targeting Islamic State objectives in the country, subsequent to an assault resulted in the deaths of two US troops and a local interpreter in the Palmyra area.
The UN estimates IS still maintains roughly 5-7 thousand fighters in Syria and Iraq.